Dr Fergus Doubal
Honorary Senior Lecturer & Consultant Stroke Physician
Research summary
Dementia and some type of strokes are caused by disease of the small blood vessels in the brain but the exact nature of this disease is unknown. We use new scanning techniques of the brain (MRI) and the back of the eye (retinal photography) to work out what happens to these blood vessels to cause dementia and stroke. By doing this we will be able to find new treatments to try to prevent both diseases.
Research aims and interests
- Understanding the pathophysiology of cerebral small vessel disease causing stroke and dementia
- Developing novel markers to predict dementia and stroke
- Developing surrogate markers to use in trials of cerebral small vessel disease
- Using advanced neuroimaging – MRI and retinal photography to delineate the pathophysiology of cerebral small vessel disease
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Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease
In:
Journal of Cerebral Blood Flow and Metabolism, pp. 0271678X2311734
DOI: https://doi.org/10.1177/0271678X231173444
Research output: Contribution to Journal › Article (Published) -
Are neuropsychiatric symptoms a marker of small vessel disease progression in older adults?: Evidence from the Lothian Birth Cohort 1936
In:
International Journal of Geriatric Psychiatry, vol. 38
DOI: https://doi.org/10.1002/gps.5855
Research output: Contribution to Journal › Article (Published) -
The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial
In:
European Stroke Journal, pp. 239698732211435
DOI: https://doi.org/10.1177/23969873221143570
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease
In:
Journal of Cerebral Blood Flow and Metabolism
DOI: https://doi.org/10.1177/0271678X221135658
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Longitudinal changes of white matter hyperintensities in sporadic small vessel disease: a systematic review and meta-analysis
In:
medrXiv
DOI: https://doi.org/10.1101/2022.03.22.22272696
Research output: Contribution to Journal › Article (E-pub ahead of print)